Researchers present novel therapeutics that rejuvenate a previously undruggable mitochondrial regulator of aging through a new mode of enzyme activation. Disclaimer: AAAS and EurekAlert! are not ...

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide 2′,3′-cGAMP during ...

This method allows specific delivery of anti-cancer prodrugs to tumor cells using affibody conjugation, to avoid unwanted off-target effects and increase the time between drug doses. Antibody-directed ...