Artificial intelligence (AI) is reshaping the scientific landscape, offering fantastic solutions to some of the most pressing global challenges. From combating climate change to transforming ...

In 2020, news headlines repeated John Moult’s words at the end of a stunning competition: Artificial intelligence had “solved” a long-standing grand challenge in biology, protein structure prediction.

On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pioneered major breakthroughs in computational chemistry. These include two researchers ...

This review provides an overview of traditional and modern methods for protein structure prediction and their characteristics and introduces the groundbreaking network features of the AlphaFold family ...

The proteins found in nature represent only a tiny fraction of the nearly limitless protein structures that could theoretically exist. By designing proteins de novo—from scratch—scientists can more ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...