The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...

A systematic method for computing the coefficients of the variance components in the expected mean squares of a hierarchical analysis of variance is described, together with a simple method of pooling ...

This section covers Twin and SNP heritability, h2 from whole genome sequencing, non-additive genetic effects and GWAS approaches. To better compare and understand the different approaches and models ...

Models to estimate heritability (twin or SNP h2) are typically linear models that can be seen as extensions of the simple linear model between two variables, from which one estimates a correlation.