ascopubs.org

Bayesian Adaptive Design for Finding the Maximum Tolerated Sequence of Doses in Multicycle Dose-Finding Clinical Trials

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL BaSyc is ...
ascopubs.org

Bayesian adaptive randomized trial design for patients with recurrent glioblastoma.

Relationship between overall survival and progression-free survival for recent NCCTG glioblastoma multiforme trials. Consolidation reduced dose whole brain radiotherapy (rdWBRT) following methotrexate ...
JSTOR Daily

A Phase I Bayesian Adaptive Design to Simultaneously Optimize Dose and Schedule Assignments Both Between and Within Patients

In traditional schedule or dose–schedule finding designs, patients are assumed to receive their assigned dose–schedule combination throughout the trial even though the combination may be found to have ...
RAPS

FDA Finalizes Guidance on Adaptive Trial Designs

The US Food and Drug Administration (FDA) last week finalized guidance on adaptive clinical trial designs for drugs and biologics. The 33-page guidance, which finalizes a draft version released for ...
STAT

Adaptive trial designs will increase clinical trial speed, safety, and effectiveness

Health care is undergoing an important and well-needed shift from a one-size-fits-all approach to more personalized, precise, patient-focused care. A similar approach needs to be implemented at scale ...