Calcium-activated chloride channels (CaCCs) play a pivotal role in a myriad of physiological processes. By responding to intracellular calcium concentration, these channels regulate epithelial ...

Structure of the calcium-activated chloride channel TMEM16A. The channel, which consists of two identical subunits, is shown in the center. The position of the membrane is indicated by lines. The ion ...

芦丁通过抑制结肠平滑肌细胞L型钙通道独立于肠神经系统和间质细胞抑制结肠收缩。实验采用离体结肠肌肉标本收缩测定和全细胞膜片钳技术，发现抑制不依赖ENS、ICC或PDGFRα+细胞，且 Bay K8644激活通道可逆转抑制效应，证实L型钙通道为关键靶点。 Kaempferol, a ...

Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and ...

Pant, S., Tam, S. W., & Long, S. B. (2025). The pentameric chloride channel BEST1 is activated by extracellular GABA. Proceedings of the National Academy of Sciences ...

The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. However, the majority of the family members turned out to be scramblases, proteins ...

The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. However, the majority of the family members turned out to be scramblases, proteins ...

In a recent study posted to the bioRxiv* preprint server, researchers investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein activity in terms of calcium ...

Biochemists have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to ...

It is vital to the regulation of cell activities through its role as a second messenger. Calcium signaling is the process whereby low cytoplasmic concentrations are deliberately increased to activate ...