蛋白偶联受体（GPCR）是一类在动物细胞中广泛存在的跨膜蛋白，也是哺乳动物中最大的膜蛋白家族。在我们体内，超过800种GPCR通过激活一系列信号通路影响着细胞行为，并调控多种生理功能。这类分布广泛的重要蛋白早已成为药物开发的热门靶点。据统计，超过30 ...

Domain Therapeutics Rebrands as Kainova Therapeutics Advancing Its Clinical Pipeline of GPCR-Modulating Therapies -- Kainova Therapeutics rebrand reflects expanding capabilities powering next stage of ...

Ottawa, Canada, July 18, 2023 (GLOBE NEWSWIRE) -- Orion Biotechnology Canada Ltd. (Orion), a drug discovery and development company unlocking the therapeutic potential of previously undruggable G ...

GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...