DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

疱疹病毒是一种广泛存在的双链DNA病毒，具有终生潜伏期，可引起多种疾病。尽管靶向DNA聚合酶的抗病毒药物是有效的，但不断增加的耐药性强调了寻找替代药物的必要性。解旋酶-引物酶抑制剂（HPIs）是一种很有前途的抗病毒药物，但其作用机制尚不明确。此外，解 ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.

For decades, biology textbooks taught that DNA’s story could be told with a single image: two elegant strands twisting in a ...

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.