Multifactorial diseases, such as coronary artery disease, can be as complex as their name suggests. How much can we hope to understand about diseases with such variation in inheritance? Aa Aa Aa ...

Genetic linkage and association studies define chromosomal regions, quantitative trait loci (QTLs), which influence the phenotype of polygenic diseases. Here, we describe a global approach to ...

In an age when the majority of monogenic human disease genes have been identified, one of the challenges for the coming generation of human geneticists will be to resolve complex polygenic and ...