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Cell | FOCAS横空出世:首个全转录组“单碱基精度”m6A功能筛选平台
纵观整项研究,我们不仅看到了FOCAS这一强大工具的威力,更看到了它所揭示的生物学复杂性。过去针对m6A的抗癌策略往往类似于“地毯式轰炸”(如全局抑制METTL3或FTO),虽然有效,但伴随着破坏管家功能的风险。
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