GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

The discovery of G protein-coupled receptor (GPCR) heteromers has revealed a new level of complexity in their functional characteristics. This review explores a variety of methodologies and live cell ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

A preliminary study of people with diabetes suggests that use of glucose-lowering GLP-1 drugs may be linked to a lower risk of developing epilepsy. The study was published in Neurology. A systematic ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical ...