本研究针对病毒载体CAR-T疗法存在的基因组整合风险及安全性问题，创新性开发了高效无痕环状mRNA（cmRNA）合成平台Hi-Scarless-PIE。该技术通过优化permuted intron-exon（PIE）自剪接系统，实现了无需外源序列插入的高产率cmRNA制备，显著延长了嵌合抗原受体（CAR）在T ...

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...