本研究通过体外重构实验，首次揭示了Mlh1-Pms1内切酶介导的错配修复（MMR）新机制。该机制不依赖于Exo1或Rad27，而是由Mlh1-Pms1在错配位点附近直接产生单链缺口，从而切除错配碱基。这一发现解释了Mlh1-Pms1在MMR中的普遍需求，并为理解其作为内切酶的直接功能 ...

Lack of Effect of Adjuvant Chemotherapy on the Elimination of Single Dormant Tumor Cells in Bone Marrow of High-Risk Breast Cancer Patients PURPOSE: Loss of function or expression of the mismatch ...

High-risk constitutional MLH1 methylation underlies a significant proportion of early-onset endometrial cancers and colorectal cancers with tumor MLH1 methylation. At the American Society of Clinical ...