Figure 1: Hydrolsysis of the acyl–enzyme intermediate formed between β-casomorphin-7 (YPFVEPI) and porcine pancreatic elastase. Here, we describe high resolution crystal structures for cryogenically ...

Scientists show enhanced enzyme diffusion after catalysis actively drives reactions away from equilibrium, offering a new ...

Enzymes accelerate reactions by helping to lower the activation energy needed to start them. But how enzymes achieve this has been the subject of intense debate. A research team from Texas and China ...

image: Synthesizing hybrid enzyme catalysts in situ to improve and expand enzymatic catalysis is an important way to address challenges of industrial biocatalysis. In this account, the construction ...

Scientists observed the characteristics of a single enzyme inside a nanopore. This revealed that the enzyme can exist in four different folded states, or conformers, that play an active role in the ...

This is a preview. Log in through your library . Abstract The mechanism of DNA cytosine-5-methylation catalyzed by the bacterial M.Hhal enzyme has been considered as a stepwise nucleophilic addition ...

Researchers have captured real-time "molecular movies" showing how an enzyme changes shape during catalysis. The study was published in Nature Communications. Subscribe to our newsletter for the ...

The snapshots reveal key reactions steps. At 0 ms, water molecules occupy the substrate-binding site. At 50 ms, a substrate-cofactor intermediate forms. At 100 ms, the product is released, and the ...

Living cells are sustained by countless chemical reactions that must be carefully regulated to maintain internal order and function. Enzymes play a ...