本研究旨在解决COVID-19患者早期诊断及预后分层困难的问题。研究人员通过血浆miRNA谱分析，发现miR-133a-3p和miR-545-3p组合可有效区分COVID-19与非COVID-19患者（AUC=0.867），而miR-142-3p和miR-423-3p组合则能早期预测患者发展为呼吸衰竭的风险（AUC=0.931）。该研究为COVID-19的 ...

Small RNA was isolated from circulating tumor exosomes using mirVana isolation kit (Ambion, Austin, TX), and this low-molecular-weight RNA–enriched fraction was used for miRNA profiling as defined by ...

Many key biological processes are impacted by miRNAs, including cell growth and proliferation, tissue differentiation, embryonic development, and apoptosis. Mutation, dysfunction, and/or dysregulation ...