N-terminal acetylation represents one of the most ubiquitous protein modifications in eukaryotic cells, with significant implications for protein stability, folding, and interactions. This covalent ...

Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging. Proteins are key to all processes in our ...

Proteins are key to all processes in our cells and understanding their functions and regulation is of major importance. “For many years, we have known that nearly all human proteins are modified by a ...

A, Under normal conditions, the Bub1 acetylation/deacetylation cycle regulates the kinase activity of Bub1 and thereby promotes the recruitment of CPC and Sgo1 to ...

Researchers from the University of Bergen (UiB) have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

A research team has developed an innovative technique that enables precise modification of specific proteins within complex biological environments. A research team led by Professor Seung Soo Oh and ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Researchers have begun to get the lay of the land in terms of what types of modifications occur, and, broadly, their effects. For example, enzymes are activated or deactivated when a phosphate group ...

Respiratory infections, pink eye, or an upset stomach may seem like unrelated, mild inconveniences, but all of these ailments share one root cause: adenovirus infection. Many of us will encounter some ...