引言在细胞每一次分裂、每一次应对内外环境挑战的喧嚣中，我们的基因组(genome)正经历着持续的修订、涂抹甚至撕裂。在癌症和许多先天性疾病的基因组中，我们常常能看到一些令人匪夷所思的混乱景象：染色体片段的诡异扩增、莫名其妙的序列插入、以及如同地震后断 ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...

For decades, biology textbooks taught that DNA’s story could be told with a single image: two elegant strands twisting in a ...

Danish researchers believe that everyone should monitor their blood folate levels. They argue that a deficiency in folic acid ...

DNA is the molecular basis of heredity, the inherited traits that pass between generations in a person's family tree. Embodied in the sequence of base pairs, DNA carries information between ...