在DNA复制过程中，复制体必须清除包括转录机制在内的障碍和路障。当复制体和转录机制发生碰撞时，转录-复制冲突（Transcription–replication conflicts，TRCs）就会发生，并且越来越被认为是哺乳动物基因组不稳定的重要来源 ...

A new LUMC study has changed our understanding of how cells work. Researchers have discovered that the CFAP20 protein acts as ...

引言在细胞每一次分裂、每一次应对内外环境挑战的喧嚣中，我们的基因组(genome)正经历着持续的修订、涂抹甚至撕裂。在癌症和许多先天性疾病的基因组中，我们常常能看到一些令人匪夷所思的混乱景象：染色体片段的诡异扩增、莫名其妙的序列插入、以及如同地震后断 ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...