近年来，将转铁蛋白受体1（Transferrin R1, TfR1）作为药物脑递送载体已成为神经系统大分子药物研发的热门策略。通过TfR1介导跨胞吞作用，将抗体或寡核苷酸“伪装”成营养物质穿过血脑屏障（Blood–Brain Barrier，BBB）进入脑内，是解决神经递送相关疾病治疗难题的 ...

转铁蛋白 (Transferrin, TF) 属于Ⅱ类跨膜糖蛋白家族，是一种由肝脏表达并分泌到血浆中的单体糖蛋白，分子量约为80 kDa，包含两个特异的高亲和力Fe3+结合位点。，其主要作用是把铁从十二指肠、白细胞和巨噬细胞中转运到其它组织。 转铁蛋白受体 (Transferrin-R, TFR ...

来自美国纪念斯隆－凯特琳癌症中心的研究人员在新研究中证实，谷氨酰胺代谢(glutaminolysis)和转铁蛋白（Transferrin）调控了铁死亡（Ferroptosis）。这一重要研究发现发布在7月9日的《分子细胞》（Molecular cell）杂志上。 生物通报道 来自美国纪念斯隆－凯特琳癌症 ...

NEW YORK--(BUSINESS WIRE)--Apertura Gene Therapy, a biotechnology company opening opportunities in genetic medicine for treating debilitating diseases with limited options, today unveiled its ...

Duetta is a highly sensitive spectrofluorometer that can be used to measure transferrin at very low concentrations. By ...

Iron is an essential element that plays a crucial role in various cellular processes including enzymatic activity, DNA repair, and oxygen transfer. To determine an individual’s iron status, clinicians ...

The de novo design of polar protein–protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for ...

For decades scientists have sought a way to sneak large drugs across the blood-brain barrier. These efforts received a boost in 2011, when researchers led by Ryan Watts at Genentech, South San ...