糖尿病视网膜病变（DR）是糖尿病最常见的微血管并发症之一，也是全球工作年龄人群致盲的首要原因。长期高血糖引发的氧化应激、慢性炎症及缺氧环境导致血管内皮生长因子（VEGF）过度表达，进而诱发视网膜新生血管形成和血管渗漏，最终造成视力损伤。尽管抗VEGF疗法已被广泛应用，但其疗效受限且存在副作用，亟需开发更安全有效的替代方案。
New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has been of keen interest ...
Predictive value of PIK3CA mutations for response to CDK4/6 inhibitors in hormone receptor-positive, HER2-negative metastatic breast cancer: A systematic review and meta-analysis. This is an ASCO ...
In this Healio Video Perspective from Retina 2026, Ehsan Rahimy, MD, discusses the potential of IL-6 inhibition for the ...
MELBOURNE, Australia and PRINCETON, N.J., July 09, 2024 (GLOBE NEWSWIRE) -- Opthea Limited (ASX/NASDAQ: OPT “Opthea”, the “Company”), a clinical-stage biopharmaceutical company developing novel ...
The dual inhibition of PD-1 and VEGF pathways by ivonescimab aims to enhance immune response and limit tumor angiogenesis, offering potential advantages over existing therapies.
Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have identified a new molecular drug ...
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