An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...

Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...

Novartis will partner with PTC Therapeutics to expand the use of PTC’s small molecule splicing platform to develop PTC’s PTC518 Huntington’s disease program and an unspecified number of related ...