本研究针对tRNA wobble尿苷(U34)修饰缺失如何通过密码子特异性翻译速率调控蛋白质稳态的机制难题，通过高精度核糖体图谱和双核糖体测序技术，首次揭示U34修饰在核糖体A位点和P位点具有差异化功能，发现亚优密码子对（如CGA-CAA）可诱发核糖体碰撞并激活Hel2 ...
The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are ...
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