Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

Silent cells deep in your spinal cord may hold a surprising key to healing after devastating injuries and brain disease. A ...

Acute systemic inflammation has long been suspected to trigger harmful processes within the brain, contributing to neurodegenerative disorders such as Alzheimer's and Parkinson's disease. A new study ...

Georgetown University's Lombardi Comprehensive Cancer Center researchers have identified a new way to reprogram T cells, ...

For more than a century, scientists have treated the brain as the undisputed command center of human evolution, with the rest ...

This illustration depicts the experimental workflow using a mouse model of LPS-induced acute systemic inflammation and PiTMaP-based metabolomics. Metabolic profiles were compared across major brain ...

—These investigators examined the simultaneous relationship between local metabolism and functional connectivity (FC) in unmedicated patients with major depressive disorder (MDD). Metabolically ...

Cancer researchers have long treated genetic chaos and epigenetic rewiring as separate engines of disease, two parallel hallmarks that help tumors grow, spread, and resist treatment. Now a new wave of ...

Sensorineural hearing loss (SNHL) is a highly prevalent sensory disorder globally, affecting over 1.5 billion people, with a ...

Researchers found that people with anxiety disorders consistently show lower choline levels in key brain regions that regulate thinking and emotions. This biochemical difference may help explain why ...