Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, ...

Figure 1: Overall structure of the GCGR–NNC0640–mAb1 complex. Figure 2: Ligand-binding mode of GCGR to NNC0640. Figure 3: Stalk and ECL1 in the full-length GCGR structure. The importance of the ...