引言当我们提到基因组时，常常会陷入一种错觉：似乎只要读懂了那2%的蛋白编码基因，我们就掌握了生命的源代码。然而，真正的生命复杂性，往往隐藏在剩下98%的非编码区域中。这些曾经被视为“垃圾DNA”的广袤荒原，实则布满了控制基因开关的精密元件。1月7日， ...

近日，马萨诸塞大学医学院领导的研究团队利用新的ENCODE数据集和增强的计算方法，将基因组中潜在调控元件的数量提升了近三倍。目前，新的数据库包含237万个人类cCRE和96.7万个小鼠cCRE。

The human genome sequence provides the underlying code for human biology. Despite intensive study, especially in identifying protein-coding genes, our understanding of the genome is far from complete, ...

Where to start? It's unlikely that you've missed any of the extensive media coverage the Encyclopedia of DNA Elements (ENCODE) project has received over the past two weeks, after the international ...

“When the first draft of the human genome was completed . . . it became immediately clear that while we had the primary sequence of the genome, or we had a draft of it . . . we needed to have an ...