Further analysis found no significant differences in complement factor deposition or serum complement levels in patients with typical CIDP compared with those with a variant. The classical or lectin ...

Cedars-Sinai investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. Science X ...

Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important ...

Light and heavy chain deposition disease (LHCDD) is a clonal plasma cell or monoclonal B-cell dyscrasia characterized by deposition of monoclonal immunoglobulin light and heavy chains. LHCDD mainly ...

This valuable study presents a deep learning framework for predicting synergistic drug combinations for cancer treatment in the AstraZeneca-Sanger (AZS) DREAM Challenge dataset. However, the evidence ...

TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...

Crystal precipitation from aqueous solution occurs through multiple pathways. Besides the classical ion -byion addition, non-classical crystallization mechanisms, such as multi-ion polymer and ...

Department of Neurology, St Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, United States Guillain-Barré syndrome (GBS) is a rare, frequently postinfectious neuromuscular ...