Asking ‘what is life?’ is a good way to start arguments in science. As a recent informal poll suggests, no two individuals ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. A research group has demonstrated that overexpression of ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

This work provides high-precision single-cell data on the relationship between DnaA activity and cell size, offering important insights for the field of cell cycle control. These findings motivate a ...

For years, the federal government has been amassing DNA profiles of noncitizens. But recently released Customs and Border Protection (CBP) data reveal that officials knowingly collected the DNA of ...

DNA, deoxyribonucleic acid, carrying encoded genetic information at molecular level, is the most significant discovery in the history of genetics. Previous researches on DNA included topics of bases, ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. A comprehensive understanding of the atomic level mechanism governing the binding ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...