新冠病毒SARS-CoV-2受体结合域（RBD）与四种瓜类种子凝集素（CSLs）的分子对接及相互作用分析显示，Luffa cylindrica lectin（PDB:1NIO）结合能最高（-24.9 kcal/mol），其糖链NAG248与病毒糖链1303、1304等形成稳定相互作用，并验证Momordia charantia种子凝集素（MCSL）的抗病毒 ...

Division of Biomolecular Sciences and Medicinal Chemistry, Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom Division of Physiology, Pharmacology ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Uncoupling protein 1 (UCP1, SLC25A7) is ...

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in China in December 2019, rapidly spread worldwide, resulting in the coronavirus disease 2019 (COVID-19) ...

The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer ...

The integration of multiple virtual screening strategies facilitates the balance of computational efficiency and prediction accuracy. In this study, we constructed an efficient and reliable ...

The ATP binding cassette transporter ABCB1 (also termed P-glycoprotein) is a physiologically essential multidrug efflux transporter of key relevance to biomedicine. Here, we report the conformational ...

Data deposition: The crystal structures of QsrR–DNA and QsrR–menadione have been deposited in the Protein Data Bank (PDB), www.pdb.org (PDB ID codes 4HQE and 4HQM ...