本研究通过结合计算机辅助药物设计（CADD）和实验验证，成功鉴定出新型αTAT1（α-微管蛋白乙酰转移酶1）调控剂，揭示了其在神经干细胞（NSCs）增殖与分化中的关键作用，为疼痛相关神经系统疾病的靶向治疗提供了新思路。

本文利用免疫信息学方法，从环形泰勒虫（Theileria annulata）蛋白质组中筛选抗原蛋白，设计新型 mRNA 疫苗。经多方面分析，该疫苗稳定、无毒、无致敏性，能有效激发体液和细胞免疫反应，为防控泰勒虫病提供新思路。 研究背景 牛泰勒虫病是热带和亚热带地区 ...

This manuscript reports important data providing evidence that a 42 amino acid region of Rev7 is necessary and sufficient for interaction with the Rad50-Mre11-Xrs2 complex in budding yeast. The ...

The workshop will consist of two technical sessions each day. Sessions will consist of 2-4 lectures each followed by a hands-on session.•The participants are requested to bring their own laptops (for ...

Thanks for the help on the last issues, Now I'm trying to get the interaction barcode as an image. I'm running this script now with an sdf file the ligands: import MDAnalysis as mda import prolif as ...

Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological processes and are implicated in numerous human diseases. Advances in structural biology, particularly the ...

The COVID-19 pandemic resulting from the spread of SARS-CoV-2 spurred devastating health and economic crises around the world. Neutralizing antibodies and licensed vaccines were developed to combat ...

The workshop will consist of two technical sessions that include 4 lectures each followed by a hands-on session. Participants are requested to bring their own laptops (for software installation and ...

Alberta RNA Research and Training Institute (ARRTI), Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada Article Views ...

A model of E. coli RfaH bound to Thermus thermophilus TEC was constructed by arbitrarily threading the NT DNA (absent in the X-ray structure) through the TEC (Belogurov et al., 2007). While subsequent ...