含有多个手性中心的螺环二烯酮结构广泛存在于天然产物和生物活性分子中。如caesalpin J和futoenone是从在传统中药中分离得到的天然产物，分别具有潜在的抗炎症活性和抑制基质金属蛋白酶的活性。一些含有苯酚取代螺环二烯酮衍生物同样具有广泛的生物活性。

Having regard to Regulation (EC) No 1935/2004 of the European Parliament and of the Council of 27 October 2004 on materials and articles intended to come into contact with food and repealing ...