The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double-blind ...

One of the fundamental purposes of biotherapeutic research, development, and production is to assure the safety and efficacy of medicinal products in clinical settings. Analytical tools are critical ...

Abstract: In this paper, the decomposition projective method based on orthogonal complement space is presented, which can refine and accelerate the original decomposition projective method when ...

Background: The complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in ...

Simply put, orthogonal validation uses additional methods that provide very different selectivity to the primary method to confirm or refute a finding. All methods are independent approaches that can ...

1 Department of Data Science and Knowledge Engineering, Maastricht University, Maastricht, Netherlands 2 Dalle Molle Institute for Artificial Intelligence, Scuola Universitaria Professionale Della ...

There is evidence that the orthogonal grid plan, which is one of the most common types of urban planning today, dates back to antiquity. Streets intersect at right angles to each other, resulting in a ...