Part II shows that the predictive validity crisis can be solved by rethinking how the industry chooses models, measures outcomes and integrates systems. Success stories from Vertex, Regeneron and ...

Drug discovery now costs 100 times more per FDA-approved drug than in 1950, despite vast advances in biology and computing. The core problem is the collapse of predictive validity in preclinical ...

Objective To study the reliability and validity of adverse childhood experiences (ACE) scores measured using a questionnaire versus abstraction of medical records, and to test whether the scores vary ...

Abstract: The sintering of copper nanoparticles for die-attach bonding has emerged as a promising soldering alternative, with mechanical properties largely influenced by pore morphologies within the ...

Introduction: The self-referential encoding task (SRET) has a number of implicit measures which are associated with various facets of depression, including depressive symptoms. While some measures ...

ABSTRACT: In child psychiatry, the use of play, a habitual activity in children, is used as a means of communication and therapy. The psychodynamic reading of a sequence of games played by a ...

This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE ...