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成纤维细胞超细胞组装体调控无瘢痕再生:药物重定位揭示修复新机制
本研究针对深部伤口愈合中瘢痕形成与再生失衡的难题,通过多模态筋膜外植体模型和高通量药物筛选,揭示了成纤维细胞通过“出芽-网状化-簇集”的超细胞动态组装协调组织修复进程。研究发现氟伐他汀、硫链丝菌素和芬苯达唑可通过阻断早期成纤维细胞前 ...
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